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In a new species, is the chromosome structure of the genome any different? What might cause the number of chromosomes to change? Would this be a mutation during reproduction? Is this something we see with simpler organisms?

A curious adult from Minnesota

April 21, 2006

Wonderful questions! They all get at the heart of what it means to be a species. What large-scale changes can happen to DNA and how? And is that important in making a new species?

These questions cover a wide array of topics. We're going to touch on human evolution. And look at how our DNA compares to apes. Finally we'll end up at bananas. Yup, bananas.

Biologists consider a species to be a group of animals that look similar and can only breed with each other successfully. DNA changes are one important factor in preventing closely related species from interbreeding.

In fact it's quite common to see some sort of large-scale change in the genome structure between species. Scientists are still undecided as to how important these DNA changes are in evolution, though.

What can happen to chromosomes in evolution?

Chromosomes are the name scientists give to a strand of DNA in a cell. Humans have 46 chromosomes in most cells. These chromosomes come in pairs meaning that humans have 23 pairs of chromosomes. We have a pair of chromosome Ones, a pair of chromosome Twos, a pair of chromosome Threes and so on.

We get one of each pair from mom and one from dad. So your mom gave you one chromosome One, one chromosome Two, and so on. Your dad gave you the other chromosome One, the other chromosome Two and so on. 

The structure of the chromosome can change in many ways. Chromosomes can break apart, and they can fuse together. A part of a chromosome can flip around or a part can move to an entirely different chromosome.

These sorts of things happen all the time. For example, some people have their chromosome 21 attached to another of their chromosomes. This doesn't affect them but it does increase the chance that they will have a child with Down syndrome (click here for more details). A DNA change like this might have helped separate humans from chimpanzees in our distant past.

If you look at the DNA sequence of a chimpanzee, it's 99% similar to us. Yet we look very different!

If we compare the chromosomes, there's one big noticeable difference. In chimps, apes, and orangutans chromosome Two seems to have split into two separate ones.

The likeliest explanation is that our primate ancestor had two separate chromosomes. During human evolution those two chromosomes fused to create our chromosome Two.

So what does that mean for evolution? Well, the fact that our chromosome structure is different is one major factor that would keep human and ape species from interbreeding. I'll explain more about that in the next section.

How do these changes happen?

Changes in chromosome structure can be caused by mistakes made during cell division. To make eggs and sperm, cells go through a special process called meiosis.

Meiosis is complicated so it shouldn't be surprising that cells occasionally make a mistake. The egg or sperm can end up with the wrong number of chromosomes. Or parts of a chromosome can go missing, some can be duplicated, or the chromosomes can get rearranged. Some mistake in our past could have happened during meiosis to cause the fusion event.

Sometimes, damage to the DNA can cause these changes. For example, it's known that radiation can cause DNA strands to break. When these breaks are repaired sometimes the cell makes mistakes and sticks the wrong pieces together.

So how do changes in chromosome structure affect evolution?

Okay, take a deep breath we're almost done. Let's get back to evolution. One important part of how new species form is that the new and old species can't breed together.

One important part of sexual reproduction is having an even number of chromosomes. Whether each chromosome has a partner chromosome is crucial.

Whenever there are odd numbers of chromosomes or mismatched pieces, there will likely be mistakes during cell division. At the last step of meiosis, one chromosome from each pair moves into the new cells. An odd number of chromosomes means that one chromosome is left unpaired. It can go to either cell.

The end result is that cells end up with the wrong number of chromosomes. And this leads to sterility or birth defects.

Let's go back to the fact that apes have a split chromosome Two. And we have one big chromosome Two. The "split" chromosome Two in apes and our big chromosome Two would have problems sorting out where each chromosome should go. The end result would be sterility or, more likely, miscarriage.

For an everyday example, take the bananas you buy at the store. These bananas have 3 copies of each chromosome in their cells which makes them seedless.

The bananas can't make any seeds because they have an odd number of chromosomes. During the cell divisions that make seeds, the unpartnered chromosomes cause all kinds of problems. As a result the seeds die.

It's likely that changes in chromosome numbers or structure are an important part of speciation. For a new species to develop there must be some reproductive barrier. This helps prevent interbreeding with the parent species. Some of those barriers could be changes in chromosome structure.

By Dr. David Tran, Stanford University

Chromosomes can change during evolution.

Bananas are seedless because they have three of each of their chromosomes.