Relatedness

I have two half-siblings and share DNA with one at 28.7% and the other at 24.6%, which I assume is normal.  However, according to the 23andMe, the brother sharing the most DNA shares only 47 segments versus 55 segments with the other brother.  Is this also considered normal?

- A curious adult from the US

February 19, 2019

The short answer is yes, that’s completely normal!

There are a couple of reasons for why this is true.

DNA Comes From Both of Our Parents

We each get half our DNA from Mom and half from Dad. This DNA is packaged into pieces called chromosomes. Instead of having one really long piece of DNA, your DNA is broken into 23 pairs of shorter pieces called chromosomes. You get one chromosome in each pair from mom, and one from dad.

This means you share 23 pieces of DNA with mom, and 23 pieces of DNA with dad. In other words, you share 23 segments of DNA with each parent. Each of these segments is really long – an entire chromosome!

Our parents each also get half their DNA from their mom and half from their dad. This means we get about ¼ from each of our grandparents. But exactly which ¼ of their DNA you inherit can vary depending on which copy of each chromosome Mom or Dad passes down at random.

Because of this, relatives will share some of their DNA, but not all of it.  Since you and your half siblings all share one parent, you have a lot of DNA that is the same.

You each randomly got about of half your DNA from this shared parent. But since your other parent is not shared, you’ll also have a lot of DNA that is different.

This means that on average you will share ¼, or 25% of your, DNA with your half siblings.

23 pairs of chromosomes, where the blue copy comes from one parents and the red comes from the other.

Recombination Shuffles Genes Around

It turns out that chromosomes aren’t passed down whole from generation to generation. You don’t have an entire chromosome from Grandma, and another chromosome from Grandpa. Instead, chromosomes get mixed up in a process called recombination

While DNA is being passed down to a baby, segments actually switch strands and shuffle the DNA around. This means that some of the DNA from Grandpa may end up on the same chromosome as DNA from Grandma. You’ll get an entire chromosome from your mom… but it will be a mixture of DNA from both her mom and her dad.

Depending on how this happens, you might get different proportions of DNA from each grandparent compared to your siblings. It’s all of this shuffling around of genetic information that makes us each such unique individuals! For more about recombination check out this previous post.

Genetic material is swapped between the two chromosomes and is then passed down a child.

DNA Segments Come In All Different Lengths and Sizes

With both of those processes in mind, you can use the amount of shared DNA to tell how someone is related to you.

On average full siblings will share about 50% of their DNA, while half siblings will share about 25% of their DNA. The actual amount may vary slightly, since recombination will shuffle the DNA differently for each child.

But why is the number of segments different than overall percent of shared DNA?

These two numbers are comparing different things. The segment count only looks at the number of shared chunks. The percentage of shared DNA looks at the total length of the chunks. It’s kind of like counting the number of words shared between two documents versus the number of letters.

So why does one half-brother share 47 segments and 29% of his DNA with you, while the other shares 55 segments and 25% DNA? The segments you share with the first brother are just longer.

Half Siblings

Full Siblings

By Natalie Deuitch, Stanford University